Adobe Animal Hospital

7712 E. Indian School Rd
Scottsdale, AZ 85251

(480)990-9561

adobeanimalhospital.com

VON WILLEBRAND's DISEASE

What is von Willebrand's disease?
Von Willebrand's disease (VWD) is the most common inherited bleeding disorder of both man and dogs. It is caused by a deficiency in the amount of a protein needed to help platelets (a blood cell used in clotting) seal broken blood vessels. The deficient protein is called von Willebrand factor antigen.Which breeds are most commonly affected by VWD?About 30 different breeds are known to be affected but the Doberman Pinscher is the breed mostcommonly associated with this disease. Of 15,000 Dobermans screened, more than 70% werefound to be carriers of the disease. Fortunately, most of these were not showing signs of thedisease at the time of testing. However, the number of Dobermans with a history of bleedingappears to be on the rise. Although Dobermans are commonly affected, they usually have themildest form of the disease. The average age at diagnosis for this breed is about four years ofage.One study showed that 30% of Scotties and 28% of Shelties had abnormally low concentrationsof von Willebrand factor. Chesapeake Bay Retrievers and Scotties are affected with the mostsevere form of the disease.

What are some of the signs of VWD?
Many dogs with VWD never show outward evidence of having the disease. Others may hemorrhagefrom the nose, vagina, urinary bladder or oral mucous membranes; prolonged bleeding after traumaor surgery is common. Females may bleed excessively after giving birth. In affected dogs with un-controlled hemorrhage, death may occur.

How is VWD diagnosed?
A screening test, called the buccal mucosal screening time, may be performed in the veterinarian's office. Prolonged bleeding on this test can raise the suspicion of the disease, especially in breeds known to be at risk. For owners who wish to confirm the diagnosis, it is possible to determine the exact amount of von Willebrand protein present in the blood.Owners of Dobermans often report that the pet has undergone routine ovariohysterectomy (spay) or neutering as a pup. An uncomplicated recovery from such procedures does not eliminate the possibility that a dog may be affected; some dogs do not become obvious "bleeders" until later in life.

Are there any situations that pose an increased risk if my dog is affected?
The avoidance of certain medications is critical for the dog with VWD. 
Drugs that may precipitate a bleeding crisis in the dog include the following:
Aspirin 
Antihistamines
Phenylbutazone 
Sulfa-based antibiotics
Ibuprofen 
Estrogens
Ampicillin/Amoxicillin
 Penicillin
Phenothiazine 
tranquilizers 
Heparin
Theophylline
Emotional stress is thought to precipitate bleeding in humans with the disease. The subjective nature of such a finding makes it difficult to know if there may be a similar association in dogs, although this remains a possibility.

What can be done to treat dogs with VWD?
In an emergency situation, transfusion of blood or fresh frozen plasma may stabilize the patient. The dog donating blood may be treated with a drug called DDAVP prior to blood collection. DDAVP will raise the level of von Willebrand factor in the donor's blood, an obvious benefit for the dog with VWD.Some dogs with VWD are able to increase the amount of protein in circulation after the administration of DDAVP, although the response is variable. At this time, it is not recommended to use this drug on a regular basis. The drug is expensive, and not all dogs will respond to it.The drugs listed above should be avoided when possible, but especially when the dog is in a bleeding crisis.

If I own a Doberman that has always been healthy, should I do something?
Since many affected Dobermans will never have bleeding problems, any recommendation to do routine testing is debatable. However, identification of dogs that have abnormal bleeding times can be very valuable if surgery is planned. Additionally, knowing that your dog is a carrier of VWD can be very important if an injury occurs.